KMID : 1130620120080020109
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Journal of Clinical Neurology 2012 Volume.8 No. 2 p.109 ~ p.115
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Ischemic Stroke in Takayasu¡¯s Arteritis: Lesion Patterns and Possible Mechanisms
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Hwang Jae-Chun
Kim Suk-Jae Bang Oh-Young Chung Chin-Sang Lee Kwang-Ho Kim Duk-Kyung Kim Gyeong-Moon
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Abstract
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Background and Purpose: The purpose of the present study was to use brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) to identify the mechanism of stroke in patients with Takayasu¡¯s arteritis (TA).
Methods: Among a retrospective cohort of 190 TA patients, 21 (3 males and 18 females) with a mean age of 39.9 years (range 15-68 years) who had acute cerebral infarctions were included in lesion pattern analyses. The patients¡¯ characteristics were reviewed, and infarction patterns and the degree of cerebral artery stenosis were evaluated. Ischemic lesions were categorized into five subgroups: cortical border-zone, internal border-zone, large lobar, large deep, and small subcortical infarctions.
Results: In total, 21 ischemic stroke events with relevant ischemic lesions on MRI were observed. The frequencies of the lesion types were as follows: large lobar (n=7, 33.3%), cortical border zone (n=6, 28.6%), internal border zone (n=1, 4.8%), small cortical (n=0, 0%), and large deep (n=7, 33.3%). MRA revealed that 11 patients had intracranial artery stenosis.
Conclusions: Hemodynamic compromise in large-artery stenosis and thromboembolic mechanisms play significant roles in ischemic stroke associated with TA.
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KEYWORD
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vasculitis, thromboembolism, intracranial artery stenosis
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